Human Sera
Cayman Chemical Fursultiamine, Purity: ≥95%, CAS: 804-30-8, 100 mg
A synthetic derivative of vitamin B1; reduces LPS-induced increases in IL-6, IL-8, and CCL2 at 100 and 20 µM, respectively; reduces the area and severity of laser-induced lesions in a mouse model of CNV at 50 mg/kg; prevents physical-fatigue loading decreases in skeletal muscle ATP levels induced by forced swimming with a weight load in rats at 50 mg/kg; enhances the protective effects of glucosamine and chondroitin sulfate on cartilage lesion formation in a rabbit model of osteoarthritis at 100 mg/kg
Cayman Chemical Se-Methylselenocysteine (hydrochloride), Purity: ≥95%, CAS: 863394-07-4, 50 mg
A selenium-containing amino acid; prevents tert-butyl hydroperoxide-induced increases in MDA levels and glutathione reductase GPX activity, as well as decreases in GSH levels, in HepG2 cells; has an additive effect on irinotecan-induced tumor growth reduction in a FaDu mouse xenograft model at 5 µg/animal per day
Cayman Chemical 4-Hydroxyphenylglyoxylic Acid, Purity: ≥95%, CAS: 15573-67-8, 50 mg
A CPT1 inhibitor and an active metabolite of oxfenicine; inhibits CPT1 in isolated rat liver mitochondria from 200 to 1,000 µM; inhibits oleate oxidation in isolated rat hepatocytes
Cayman Chemical Colchicoside, Purity: ≥98%, CAS: 477-29-2, 50 mg
A glycoside form of 3-demethylcolchicine; does not displace [3H]-colchicine from rat brain tubulin in vitro at 25 μM; increases CYP2C9 and CYP2E1 levels in primary human hepatocytes at 1 and 10 μM
Cayman Chemical Suberylglycine, Purity: ≥95%, CAS: 60317-54-6, 100 mg
A glycine-conjugated form of suberic acid; urinary levels are increased in patients with MCAD deficiency
Cayman Chemical MDDMA (hydrochloride), Purity: ≥98%, CAS: 74341-79-0, 50 mg
A centrally active substituted methylenedioxyphenethylamine that is structurally similar to 3,4-MDMA; intended for research and forensic applications
Cayman Chemical Tiplaxtinin, Purity: ≥98%, CAS: 393105-53-8, 50 mg
A PAI-1 inhibitor (IC50 = 2.7 µM for the human enzyme); inhibits differentiation of human adipocytes at 5 µM; reduces tumor growth and microvessel density in a T24 bladder cancer mouse xenograft model at 5 and 20 mg/kg; prevents carotid artery occlusion, increases the time to occlusive thrombosis, and decreases the thrombus size in a rat model of ferric chloride-induced arterial thrombosis at 1 mg/kg
Cayman Chemical Cordycepin, Purity: ≥98%, CAS: 73-03-0, 100 mg
A nucleoside analog with diverse biological activities; is converted to cordycepin triphosphate, which inhibits ATP-dependent DNA and RNA synthesis; incorporates into DNA and RNA in SK-HEP-1 cells; is active against B. subtilis at 0.1-1 mg/ml; increases IL-10 secretion and mRNA expression in isolated human PBMCs at 24 µg/ml; increases survival of mice infected with C. albicans or C. krusei at 1 mg/kg per day
Cayman Chemical Dronedarone (hydrochloride), Purity: ≥98%, CAS: 141625-93-6, 100 mg
An antiarrhythmic agent; inhibits muscarinic acetylcholine receptor-dependent potassium currents induced by carbachol or intracellular loading of GTPγS in single cells isolated from guinea pig atria (IC50s = 0.1 and 1 µM, respectively); reduces sinus frequency and prolongs APD in isolated rabbit ventricular myocardium at 50 and 100 mg/kg; increases atrial APD and the AERP in a dog model of atrial fibrillation
Cayman Chemical 2-Nonylquinolin-4(1H)-one, Purity: ≥95%, CAS: 55396-45-7, 50 mg
A quinolone alkaloid; active against HCV (IC50 = 1.4 µg/ml) and L. gongylophorus; inhibits TPA- and A23187-induced NFAT activation in Jurkat cells but not LPS-induced NF-κB activation in RAW 264.7 cells (IC50s = 3.44 and >100 µM, respectively, in reporter assays)
Cayman Chemical 5′-O-(4,4′-Dimethoxytrityl)thymidine, Purity: ≥98%, CAS: 40615-39-2, 50 mg
A derivative of thymidine and synthetic precursor; has been used as a precursor in the synthesis of oligo-2’-deoxyribonucleotides and phosphoramidate derivatives
Cayman Chemical Nicergoline, Purity: ≥98%, CAS: 27848-84-6, 100 mg
An α1-AR antagonist; binds to α1-ARs in rat brain membranes (Ki = 12.5 nM); inhibits α1-AR agonist-induced contractions in endothelium-denuded isolated rat aortic rings and perfused mesenteric vascular beds (pA2s = 8.6 and 11.1, respectively); inhibits cirazoline-induced pressor responses in rats at 0.5 µg/kg per minute, i.v.; improves postischemic glutamate uptake and reduces neuronal cell death and mortality in a rat model of global brain ischemia induced by mild hyperthermia at 32 mg/kg; increases corneal NGF levels and accelerates corneal wound healing in a rat model of ocular injury
Cayman Chemical Tri-GalNAc(OAc)3 (trifluoroacetate salt), Purity: ≥98%, CAS: 1159408-65-7, 100 mg
An intermediate in the synthesis of LYTACs with anticancer activity
Cayman Chemical 7-Deaza-7-iodo-2'-deoxyguanosine, Purity: ≥98%, CAS: 172163-62-1, 100 mg
A nucleoside derivative; has been used as an intermediate in the synthesis of fluorescent nucleotide derivatives for incorporation into single- or double-stranded oligonucleotides
Cayman Chemical Swertiamarin, Purity: ≥98%, CAS: 17388-39-5, 50 mg
A secoiridoid glycoside with diverse biological activities; scavenges ABTS radicals and hydrogen peroxide (IC50s = 2.83 and 5.7 μM, respectively); inhibits NO production in IL-1β-stimulated FLSs isolated from rat hindpaw at 50 μg/ml; inhibits oleate-induced lipid droplet and triglyceride accumulation in HepG2 cells at 25 μg/ml; decreases liver lipid accumulation, ballooning degeneration, and TNF-α and IL-6 levels in a mouse model of fructose-induced NAFLD at 50 mg/kg per day; decreases fasting blood glucose and serum cholesterol levels in rat model of STZ-induced diabetes at 50 mg/kg per day